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Mdm2 and CHIP have been identi?ed as themajor E3 ubiquitin ligases for mutant p53 since destabilization of mutant p53 ispartially inhibited by knockdown of Mdm2 or CHIP [ 23]. (2002) Novel antibodies to synucleinshow abundant striatal pathology in Lewy body diseases. The lastsevere exacerbation of my MS occurred while I was goingthrough my divorce

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