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This diagram illustratesthree components ofa typical synapse.The presynapticknob islocatedat thedistalendoftheaxonfromwhich neurotransmitters arereleased.Thepresynapticelementoftheaxonischaracterized by thepresenceofnumerousneurotransmitter-containing synapticvesicles.The plasma membrane ofthe presynaptic knob is recycled by theformation ofclathrin-coatedendocytotic vesicles.The synaptic cleft separates the presynaptic knob of the axon from the postsynaptic membrane ofthe dendrite.The postsynapticmembrane of the dendrite is frequently characterized by a postsynaptic density and contains receptors with an affinity for the neurotransmitters. (2003b) Cognitivereserve modulates functional brain responses during memorytasks: a PET study in healthy young and elderly subjects

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